General Information of the Compound
Compound ID
CP0428450
Compound Name
(-)-6-(propyl(2-(4-(4-(pyridin-4-yl)-phenyl)piperazin-1-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol
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Structure
Formula
C30H38N4O
Molecular Weight
470.661
Canonical SMILES
CCCN(CCN1CCN(CC1)c1ccc(cc1)-c1ccncc1)C1CCc2c(O)cccc2C1
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InChI
InChI=1S/C30H38N4O/c1-2-16-33(28-10-11-29-26(23-28)4-3-5-30(29)35)20-17-32-18-21-34(22-19-32)27-8-6-24(7-9-27)25-12-14-31-15-13-25/h3-9,12-15,28,35H,2,10-11,16-23H2,1H3
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InChIKey
SRCFLOVZPHBHHM-UHFFFAOYSA-N
Physicochemical Property
logP
4.8457
Rotatable Bonds
8
Heavy Atom Count
35
Polar Areas
42.84
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 52948338
ChEMBL ID
CHEMBL1255028
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00957, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 13.2 nM
   TI
   LI
   LO
   TS
Protein ID: PT01366, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 1.53 nM
   TI
   LI
   LO
   TS