General Information of the Compound
Compound ID
CP0428173
Compound Name
(4S)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[6-[(1S,2S)-2-(hydroxymethyl)cyclopropyl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxopentanoic acid
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Structure
Formula
C27H33N5O7
Molecular Weight
539.589
Canonical SMILES
CCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(nc(n1)-c1ccccc1)[C@H]1C[C@@H]1CO
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InChI
InChI=1S/C27H33N5O7/c1-2-39-27(38)32-12-10-31(11-13-32)26(37)20(8-9-23(34)35)30-25(36)22-15-21(19-14-18(19)16-33)28-24(29-22)17-6-4-3-5-7-17/h3-7,15,18-20,33H,2,8-14,16H2,1H3,(H,30,36)(H,34,35)/t18-,19+,20+/m1/s1
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InChIKey
CLFQIBKGKKHQHZ-AABGKKOBSA-N
Physicochemical Property
logP
1.5033
Rotatable Bonds
10
Heavy Atom Count
39
Polar Areas
162.26
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118710244
ChEMBL ID
CHEMBL3322649
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 23 nM
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