General Information of the Compound
Compound ID
CP0428123
Compound Name
ethyl 3-benzyl-4-methyl-10-[4-(trifluoromethyl)phenyl]-1,4,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraene-3-carboxylate
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Structure
Formula
C26H23F3N4O2
Molecular Weight
480.49
Canonical SMILES
CCOC(=O)C1(Cc2ccccc2)N(C)Cc2cnc3c(cnn3c12)-c1ccc(cc1)C(F)(F)F
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InChI
InChI=1S/C26H23F3N4O2/c1-3-35-24(34)25(13-17-7-5-4-6-8-17)22-19(16-32(25)2)14-30-23-21(15-31-33(22)23)18-9-11-20(12-10-18)26(27,28)29/h4-12,14-15H,3,13,16H2,1-2H3
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InChIKey
XCEHXJCCOGXTBG-UHFFFAOYSA-N
Physicochemical Property
logP
4.8616
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
59.73
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118720420
ChEMBL ID
CHEMBL3354792
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 214 nM
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