General Information of the Compound
Compound ID
CP0427010
Compound Name
(4S)5-[4-(Butoxycarbonyl)iperazin-1-yl]-4-{[(4-{[1-(ethylsulfonyl)piperidin-4-yl]methoxy}-6-phenylpyridin-2-yl)carbonyl]-amino}-5-oxopentanoic Acid
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Structure
Formula
C34H47N5O9S
Molecular Weight
701.843
Canonical SMILES
CCCCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(OCC2CCN(CC2)S(=O)(=O)CC)cc(n1)-c1ccccc1
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InChI
InChI=1S/C34H47N5O9S/c1-3-5-21-47-34(44)38-19-17-37(18-20-38)33(43)28(11-12-31(40)41)36-32(42)30-23-27(22-29(35-30)26-9-7-6-8-10-26)48-24-25-13-15-39(16-14-25)49(45,46)4-2/h6-10,22-23,25,28H,3-5,11-21,24H2,1-2H3,(H,36,42)(H,40,41)/t28-/m0/s1
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InChIKey
GONXYMXWSYLSQT-NDEPHWFRSA-N
Physicochemical Property
logP
3.2332
Rotatable Bonds
15
Heavy Atom Count
49
Polar Areas
175.75
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
49

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45142451
SID: 92392442
ChEMBL ID
CHEMBL600576
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 5.3 nM
   TI
   LI
   LO
   TS