General Information of the Compound
Compound ID
CP0426889
Compound Name
N-[4-(2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaen-5-yl)butyl]naphthalene-2-carboxamide
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Structure
Formula
C32H33N3O
Molecular Weight
475.636
Canonical SMILES
O=C(NCCCCN1CCN2C(C1)c1ccccc1Cc1ccccc21)c1ccc2ccccc2c1
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InChI
InChI=1S/C32H33N3O/c36-32(28-16-15-24-9-1-2-10-25(24)21-28)33-17-7-8-18-34-19-20-35-30-14-6-4-12-27(30)22-26-11-3-5-13-29(26)31(35)23-34/h1-6,9-16,21,31H,7-8,17-20,22-23H2,(H,33,36)
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InChIKey
RWDSDWDANDUVKH-UHFFFAOYSA-N
Physicochemical Property
logP
5.8175
Rotatable Bonds
6
Heavy Atom Count
36
Polar Areas
35.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44436745
ChEMBL ID
CHEMBL238859
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 1324 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS