General Information of the Compound
Compound ID
CP0426888
Compound Name
2-[4-(4-benzhydrylpiperazin-1-yl)butyl]isoindole-1,3-dione
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Structure
Formula
C29H31N3O2
Molecular Weight
453.586
Canonical SMILES
O=C1N(CCCCN2CCN(CC2)C(c2ccccc2)c2ccccc2)C(=O)c2ccccc12
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InChI
InChI=1S/C29H31N3O2/c33-28-25-15-7-8-16-26(25)29(34)32(28)18-10-9-17-30-19-21-31(22-20-30)27(23-11-3-1-4-12-23)24-13-5-2-6-14-24/h1-8,11-16,27H,9-10,17-22H2
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InChIKey
OBIIIJJDTMSOQS-UHFFFAOYSA-N
Physicochemical Property
logP
4.47
Rotatable Bonds
8
Heavy Atom Count
34
Polar Areas
43.86
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 2822063
SID: 57270232
ChEMBL ID
CHEMBL240377
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 598 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 47.3 nM
   TI
   LI
   LO
   TS