General Information of the Compound
Compound ID
CP0426828
Compound Name
(3S)-3-[5-[(2-bromo-4,5-dimethoxyphenyl)sulfonylmethyl]-2-chlorophenoxy]-1-methylpyrrolidine
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Structure
Formula
C20H23BrClNO5S
Molecular Weight
504.83
Canonical SMILES
COc1cc(Br)c(cc1OC)S(=O)(=O)Cc1ccc(Cl)c(O[C@H]2CCN(C)C2)c1
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InChI
InChI=1S/C20H23BrClNO5S/c1-23-7-6-14(11-23)28-17-8-13(4-5-16(17)22)12-29(24,25)20-10-19(27-3)18(26-2)9-15(20)21/h4-5,8-10,14H,6-7,11-12H2,1-3H3/t14-/m0/s1
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InChIKey
SDTZEZIBBCCXPG-AWEZNQCLSA-N
Physicochemical Property
logP
4.1765
Rotatable Bonds
7
Heavy Atom Count
29
Polar Areas
65.07
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71579744
SID: 163625165
ChEMBL ID
CHEMBL2348503
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02463, Urotensin-2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 742 nM
   TI
   LI
   LO
   TS
CL000615 Chem-2 Homo sapiens (Human)  1
1
IC50 = 1280 nM
   TI
   LI
   LO
   TS