General Information of the Cell Line
Cell Line ID
CL000615
Cell Line Name
Chem-2
Synonyms
ChemiSCREEN Chem-2
Wild-type control Chem-2 cell line
ChemiSCREEN Chem-2 parental cell line
Category
Undefined cell line type
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_L475
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT02463, Urotensin-2 receptor
Compound ID Compound Name Compound Formula
CP0272883
(R)-2-bromo-4,5-dimethoxy-N-(3-(1-methylpyrrolidin-3-yloxy)-4-(trifluoromethyl)phenyl)benzenesulfonamide
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C20H22BrF3N2O5S
 1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0448230
2-bromo-N-[4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxyphenyl]-4,5-dimethoxybenzenesulfonamide
   Show/Hide
C19H22BrClN2O5S
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0410675
(3R)-3-[5-[(2-bromo-4,5-dimethoxyphenyl)sulfonylmethyl]-2-chlorophenoxy]-1-methylpyrrolidine
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C20H23BrClNO5S
 1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
CP0451214
2-bromo-N-[3-[2-(dimethylamino)ethoxy]-4-(trifluoromethyl)phenyl]-4,5-dimethoxybenzenesulfonamide
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C19H22BrF3N2O5S
 1
1
IC50 = 134 nM
   TI
   LI
   LO
   TS
CP0410676
2-bromo-4,5-dimethoxy-N-[3-[(3R)-1-methylpiperidin-3-yl]oxy-4-(trifluoromethyl)phenyl]benzenesulfonamide
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C21H24BrF3N2O5S
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0432209
N-[(5-chlorothiophen-2-yl)methyl]-3-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)aniline
   Show/Hide
C17H18ClF3N2OS
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0445148
N-[(2-bromo-4,5-dimethoxyphenyl)methyl]-3-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)aniline
   Show/Hide
C21H24BrF3N2O3
 1
1
IC50 = 217 nM
   TI
   LI
   LO
   TS
CP0426827
N-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxyaniline
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C20H24BrClN2O3
 1
1
IC50 = 237 nM
   TI
   LI
   LO
   TS
CP0422559
(3R)-3-[5-[(2-bromo-4,5-dimethoxyphenyl)sulfinylmethyl]-2-chlorophenoxy]-1-methylpyrrolidine
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C20H23BrClNO4S
 1
1
IC50 = 245 nM
   TI
   LI
   LO
   TS
CP0499778
(3R)-3-[5-[(2-bromo-4,5-dimethoxyphenyl)sulfanylmethyl]-2-chlorophenoxy]-1-methylpyrrolidine
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C20H23BrClNO3S
 1
1
IC50 = 440 nM
   TI
   LI
   LO
   TS
CP0499777
N-[(6-bromo-1,3-benzodioxol-5-yl)methyl]-3-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)aniline
   Show/Hide
C20H20BrF3N2O3
 1
1
IC50 = 450 nM
   TI
   LI
   LO
   TS
CP0447543
4-chloro-3-[2-(dimethylamino)ethoxy]-N-[[2-(trifluoromethyl)phenyl]methyl]aniline
   Show/Hide
C18H20ClF3N2O
 1
1
IC50 = 520 nM
   TI
   LI
   LO
   TS
CP0499776
3-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)-N-[(2,4,5-trimethoxyphenyl)methyl]aniline
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C22H27F3N2O4
 1
1
IC50 = 520 nM
   TI
   LI
   LO
   TS
CP0422556
N-[(5-bromo-1,3-benzodioxol-4-yl)methyl]-3-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)aniline
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C20H20BrF3N2O3
 1
1
IC50 = 620 nM
   TI
   LI
   LO
   TS
CP0447577
(3R)-3-[5-[(2-bromo-4,5-dimethoxyphenoxy)methyl]-2-chlorophenoxy]-1-methylpyrrolidine
   Show/Hide
C20H23BrClNO4
 1
1
IC50 = 669 nM
   TI
   LI
   LO
   TS
CP0426823
N-[(3-methoxyphenyl)methyl]-3-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)aniline
   Show/Hide
C20H23F3N2O2
 1
1
IC50 = 691 nM
   TI
   LI
   LO
   TS
CP0426824
N-[(4-methoxyphenyl)methyl]-3-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)aniline
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C20H23F3N2O2
 1
1
IC50 = 714 nM
   TI
   LI
   LO
   TS
CP0451194
2-bromo-4,5-dimethoxy-N-[3-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-(trifluoromethyl)phenyl]benzenesulfonamide
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C21H24BrF3N2O5S
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0426825
N-[(2-bromophenyl)methyl]-3-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)aniline
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C19H20BrF3N2O
 1
1
IC50 = 821 nM
   TI
   LI
   LO
   TS
CP0432204
2-bromo-4,5-dimethoxy-N-[3-[2-(4-methylpiperazin-1-yl)ethoxy]-4-(trifluoromethyl)phenyl]benzenesulfonamide
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C22H27BrF3N3O5S
 1
1
IC50 = 840 nM
   TI
   LI
   LO
   TS
CP0426826
N-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-chloro-3-[2-(dimethylamino)ethoxy]aniline
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C19H24BrClN2O3
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0426828
(3S)-3-[5-[(2-bromo-4,5-dimethoxyphenyl)sulfonylmethyl]-2-chlorophenoxy]-1-methylpyrrolidine
   Show/Hide
C20H23BrClNO5S
 1
1
IC50 = 1280 nM
   TI
   LI
   LO
   TS
CP0473451
N-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-chloro-3-[(3S)-1-methylpyrrolidin-3-yl]oxyaniline
   Show/Hide
C20H24BrClN2O3
 1
1
IC50 = 1350 nM
   TI
   LI
   LO
   TS
CP0514135
2-bromo-4,5-dimethoxy-N-[3-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(trifluoromethyl)phenyl]benzenesulfonamide
   Show/Hide
C21H24BrF3N2O5S
 1
1
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0432210
3-[(3S)-1-methylpyrrolidin-3-yl]oxy-N-(thiophen-2-ylmethyl)-4-(trifluoromethyl)aniline
   Show/Hide
C17H19F3N2OS
 1
1
IC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0432205
2-bromo-N-[[4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxyphenyl]methyl]-4,5-dimethoxyaniline
   Show/Hide
C20H24BrClN2O3
 1
1
IC50 = 3060 nM
   TI
   LI
   LO
   TS
CP0422557
N-[(2-bromophenyl)methyl]-4-chloro-3-[2-(dimethylamino)ethoxy]aniline
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C17H20BrClN2O
 1
1
IC50 = 3500 nM
   TI
   LI
   LO
   TS
CP0499774
2-bromo-4,5-dimethoxy-N-[3-(2-morpholin-4-ylethoxy)-4-(trifluoromethyl)phenyl]benzenesulfonamide
   Show/Hide
C21H24BrF3N2O6S
 1
1
IC50 = 6200 nM
   TI
   LI
   LO
   TS
CP0422558
N-benzyl-4-chloro-3-[2-(dimethylamino)ethoxy]aniline
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C17H21ClN2O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0432206
2-bromo-N-[3-fluoro-4-(trifluoromethyl)phenyl]-4,5-dimethoxybenzenesulfonamide
   Show/Hide
C15H12BrF4NO4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0499775
2-bromo-4,5-dimethoxy-N-[3-[(3S)-1-methylpiperidin-3-yl]oxy-4-(trifluoromethyl)phenyl]benzenesulfonamide
   Show/Hide
C21H24BrF3N2O5S
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line