General Information of the Compound
Compound ID
CP0432204
Compound Name
2-bromo-4,5-dimethoxy-N-[3-[2-(4-methylpiperazin-1-yl)ethoxy]-4-(trifluoromethyl)phenyl]benzenesulfonamide
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Structure
Formula
C22H27BrF3N3O5S
Molecular Weight
582.439
Canonical SMILES
COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(c(OCCN2CCN(C)CC2)c1)C(F)(F)F
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InChI
InChI=1S/C22H27BrF3N3O5S/c1-28-6-8-29(9-7-28)10-11-34-18-12-15(4-5-16(18)22(24,25)26)27-35(30,31)21-14-20(33-3)19(32-2)13-17(21)23/h4-5,12-14,27H,6-11H2,1-3H3
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InChIKey
QHYQKQSJMGRGDT-UHFFFAOYSA-N
Physicochemical Property
logP
3.9121
Rotatable Bonds
9
Heavy Atom Count
35
Polar Areas
80.34
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71580133
SID: 163625637
ChEMBL ID
CHEMBL2348527
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02463, Urotensin-2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000615 Chem-2 Homo sapiens (Human)  1
1
IC50 = 840 nM
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