General Information of the Compound
Compound ID
CP0424536
Compound Name
(4S)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[(2-phenyl-6-thiophen-3-ylpyrimidine-4-carbonyl)amino]pentanoic acid
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Structure
Formula
C27H29N5O6S
Molecular Weight
551.625
Canonical SMILES
CCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(nc(n1)-c1ccccc1)-c1ccsc1
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InChI
InChI=1S/C27H29N5O6S/c1-2-38-27(37)32-13-11-31(12-14-32)26(36)20(8-9-23(33)34)30-25(35)22-16-21(19-10-15-39-17-19)28-24(29-22)18-6-4-3-5-7-18/h3-7,10,15-17,20H,2,8-9,11-14H2,1H3,(H,30,35)(H,33,34)/t20-/m0/s1
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InChIKey
MZJBTSWSBMERIZ-FQEVSTJZSA-N
Physicochemical Property
logP
3.136
Rotatable Bonds
9
Heavy Atom Count
39
Polar Areas
142.03
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67460624
ChEMBL ID
CHEMBL3322632
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 11 nM
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