General Information of the Compound
Compound ID
CP0422579
Compound Name
US9139578, 15
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Structure
Formula
C21H23N7O4S2
Molecular Weight
501.594
Canonical SMILES
CC(C)NC(=O)NC(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1
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InChI
InChI=1S/C21H23N7O4S2/c1-12(2)24-21(29)26-18(19-28-27-17(32-19)11-23-34(22,30)31)20-25-15-9-8-14(10-16(15)33-20)13-6-4-3-5-7-13/h3-10,12,18,23H,11H2,1-2H3,(H2,22,30,31)(H2,24,26,29)
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InChIKey
XNERXWPOMDVTMC-UHFFFAOYSA-N
Physicochemical Property
logP
2.4364
Rotatable Bonds
8
Heavy Atom Count
34
Polar Areas
165.13
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
8
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 72947955
ChEMBL ID
CHEMBL3958234
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01303, Endothelial lipase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS