General Information of the Compound
Compound ID
CP0420769
Compound Name
4-[3-[4-[1-[(E)-4-[2-[4-(3-morpholin-4-ylpropoxy)phenyl]benzimidazol-1-yl]but-2-enyl]benzimidazol-2-yl]phenoxy]propyl]morpholine
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Structure
Formula
C44H50N6O4
Molecular Weight
726.922
Canonical SMILES
C(COc1ccc(cc1)-c1nc2ccccc2n1C\C=C\Cn1c(nc2ccccc12)-c1ccc(OCCCN2CCOCC2)cc1)CN1CCOCC1
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InChI
InChI=1S/C44H50N6O4/c1-3-11-41-39(9-1)45-43(35-13-17-37(18-14-35)53-29-7-21-47-25-31-51-32-26-47)49(41)23-5-6-24-50-42-12-4-2-10-40(42)46-44(50)36-15-19-38(20-16-36)54-30-8-22-48-27-33-52-34-28-48/h1-6,9-20H,7-8,21-34H2/b6-5+
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InChIKey
CQTGVKLTMSDNTL-AATRIKPKSA-N
Physicochemical Property
logP
7.1786
Rotatable Bonds
16
Heavy Atom Count
54
Polar Areas
79.04
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
10
Complexity
54

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44319482
ChEMBL ID
CHEMBL314439
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 3333 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 2040 nM
   TI
   LI
   LO
   TS