General Information of the Compound
Compound ID
CP0418179
Compound Name
methyl (3S)-3-[(3-fluorophenyl)methyl]-11-(2-hydroxypropan-2-yl)-10-[4-(trifluoromethyl)phenyl]-1,4,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraene-3-carboxylate
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Structure
Formula
C27H24F4N4O3
Molecular Weight
528.506
Canonical SMILES
COC(=O)[C@@]1(Cc2cccc(F)c2)NCc2cnc3c(c(nn3c12)C(C)(C)O)-c1ccc(cc1)C(F)(F)F
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InChI
InChI=1S/C27H24F4N4O3/c1-25(2,37)21-20(16-7-9-18(10-8-16)27(29,30)31)23-32-13-17-14-33-26(24(36)38-3,22(17)35(23)34-21)12-15-5-4-6-19(28)11-15/h4-11,13,33,37H,12,14H2,1-3H3/t26-/m0/s1
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InChIKey
TZZVBRXOULSCQF-SANMLTNESA-N
Physicochemical Property
logP
4.4958
Rotatable Bonds
5
Heavy Atom Count
38
Polar Areas
88.75
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118720427
ChEMBL ID
CHEMBL3354800
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 530 nM
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