General Information of the Compound
Compound ID
CP0417886
Compound Name
2-(2-(bis(4-fluorophenyl)methyl)-4-(2-(pyrrolidin-1-yl)pyridin-4-yl)thiazol-5-yl)acetic acid
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Structure
Formula
C27H23F2N3O2S
Molecular Weight
491.563
Canonical SMILES
OC(=O)Cc1sc(nc1-c1ccnc(c1)N1CCCC1)C(c1ccc(F)cc1)c1ccc(F)cc1
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InChI
InChI=1S/C27H23F2N3O2S/c28-20-7-3-17(4-8-20)25(18-5-9-21(29)10-6-18)27-31-26(22(35-27)16-24(33)34)19-11-12-30-23(15-19)32-13-1-2-14-32/h3-12,15,25H,1-2,13-14,16H2,(H,33,34)
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InChIKey
MWKAFMGLLZSPHJ-UHFFFAOYSA-N
Physicochemical Property
logP
5.8908
Rotatable Bonds
7
Heavy Atom Count
35
Polar Areas
66.32
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46229943
ChEMBL ID
CHEMBL602137
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01171, Prostaglandin D2 receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000771 HEK385-7 Homo sapiens (Human)  2
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
2
IC50 > 100000 nM
   TI
   LI
   LO
   TS