General Information of the Compound
Compound ID
CP0410984
Compound Name
N-[3-(3,4-dichlorophenyl)propyl]-4-hydroxy-1-(2-morpholin-4-ylethyl)-5-oxo-2H-pyrrole-3-carboxamide
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Structure
Formula
C20H25Cl2N3O4
Molecular Weight
442.343
Canonical SMILES
OC1=C(CN(CCN2CCOCC2)C1=O)C(=O)NCCCc1ccc(Cl)c(Cl)c1
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InChI
InChI=1S/C20H25Cl2N3O4/c21-16-4-3-14(12-17(16)22)2-1-5-23-19(27)15-13-25(20(28)18(15)26)7-6-24-8-10-29-11-9-24/h3-4,12,26H,1-2,5-11,13H2,(H,23,27)
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InChIKey
GEBOFGZVLSPGBU-UHFFFAOYSA-N
Physicochemical Property
logP
2.0287
Rotatable Bonds
8
Heavy Atom Count
29
Polar Areas
82.11
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89489300
ChEMBL ID
CHEMBL4213958
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01303, Endothelial lipase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
IC50 = 190 nM
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