General Information of the Compound
Compound ID
CP0409214
Compound Name
N-[4-[4-(8-oxo-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-2-ylidene)piperidin-1-yl]butyl]naphthalene-2-carboxamide
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Structure
Formula
C33H32N2O2S
Molecular Weight
520.698
Canonical SMILES
O=C(NCCCCN1CCC(CC1)=C1c2ccsc2C(=O)Cc2ccccc12)c1ccc2ccccc2c1
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InChI
InChI=1S/C33H32N2O2S/c36-30-22-26-9-3-4-10-28(26)31(29-15-20-38-32(29)30)24-13-18-35(19-14-24)17-6-5-16-34-33(37)27-12-11-23-7-1-2-8-25(23)21-27/h1-4,7-12,15,20-21H,5-6,13-14,16-19,22H2,(H,34,37)
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InChIKey
XFXJOECCOKNBMS-UHFFFAOYSA-N
Physicochemical Property
logP
6.748
Rotatable Bonds
6
Heavy Atom Count
38
Polar Areas
49.41
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44436753
ChEMBL ID
CHEMBL430371
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 10.9 nM
   TI
   LI
   LO
   TS