General Information of the Compound
Compound ID
CP0408776
Compound Name
N-[4-[[2-(dimethylamino)-5,6,7,8-tetrahydroquinazolin-6-yl]-propylamino]butyl]-4-phenylbenzamide
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Structure
Formula
C30H39N5O
Molecular Weight
485.676
Canonical SMILES
CCCN(CCCCNC(=O)c1ccc(cc1)-c1ccccc1)C1CCc2nc(ncc2C1)N(C)C
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InChI
InChI=1S/C30H39N5O/c1-4-19-35(27-16-17-28-26(21-27)22-32-30(33-28)34(2)3)20-9-8-18-31-29(36)25-14-12-24(13-15-25)23-10-6-5-7-11-23/h5-7,10-15,22,27H,4,8-9,16-21H2,1-3H3,(H,31,36)
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InChIKey
YUOYSSGZLHUBKV-UHFFFAOYSA-N
Physicochemical Property
logP
4.9891
Rotatable Bonds
11
Heavy Atom Count
36
Polar Areas
61.36
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44325021
ChEMBL ID
CHEMBL90897
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1584.89 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 25.12 nM
   TI
   LI
   LO
   TS