General Information of the Compound
Compound ID
CP0406281
Compound Name
N-[4-[(2-tert-butyl-5,6,7,8-tetrahydroquinazolin-6-yl)-propylamino]butyl]-4-phenylbenzamide
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Structure
Formula
C32H42N4O
Molecular Weight
498.715
Canonical SMILES
CCCN(CCCCNC(=O)c1ccc(cc1)-c1ccccc1)C1CCc2nc(ncc2C1)C(C)(C)C
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InChI
InChI=1S/C32H42N4O/c1-5-20-36(28-17-18-29-27(22-28)23-34-31(35-29)32(2,3)4)21-10-9-19-33-30(37)26-15-13-25(14-16-26)24-11-7-6-8-12-24/h6-8,11-16,23,28H,5,9-10,17-22H2,1-4H3,(H,33,37)
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InChIKey
KWNJMHODRWLBPT-UHFFFAOYSA-N
Physicochemical Property
logP
6.2206
Rotatable Bonds
10
Heavy Atom Count
37
Polar Areas
58.12
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44324802
ChEMBL ID
CHEMBL92439
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1584.89 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 12.59 nM
   TI
   LI
   LO
   TS