General Information of the Compound
Compound ID
CP0405384
Compound Name
CHEMBL86183
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Formula
C30H35FN4O2
Molecular Weight
502.634
Canonical SMILES
CC(=O)Nc1cccc(\C=C\C(=O)N[C@H]2CC[C@H](CCN3CCc4ccc(cc4CC3)C#N)CC2)c1F
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InChI
InChI=1S/C30H35FN4O2/c1-21(36)33-28-4-2-3-25(30(28)31)9-12-29(37)34-27-10-6-22(7-11-27)13-16-35-17-14-24-8-5-23(20-32)19-26(24)15-18-35/h2-5,8-9,12,19,22,27H,6-7,10-11,13-18H2,1H3,(H,33,36)(H,34,37)/b12-9+/t22-,27-
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InChIKey
HKAVEMLHBNPBSZ-PTTOYHQWSA-N
Physicochemical Property
logP
4.83488
Rotatable Bonds
7
Heavy Atom Count
37
Polar Areas
85.23
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
SID: 15382312
ChEMBL ID
CHEMBL86183
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 501.19 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3.981 nM
   TI
   LI
   LO
   TS