General Information of the Compound
Compound ID
CP0404256
Compound Name
CHEMBL78195
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Formula
C26H39Cl2N3O
Molecular Weight
480.524
Canonical SMILES
Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)NC(=O)C3CCCCCC3)CC2)c1Cl
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InChI
InChI=1S/C26H39Cl2N3O/c27-23-8-5-9-24(25(23)28)31-18-16-30(17-19-31)15-14-20-10-12-22(13-11-20)29-26(32)21-6-3-1-2-4-7-21/h5,8-9,20-22H,1-4,6-7,10-19H2,(H,29,32)/t20-,22-
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InChIKey
ARXSWHRTJLWTMT-AQYVVDRMSA-N
Physicochemical Property
logP
6.1509
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
35.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL78195
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 12 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4.8 nM
   TI
   LI
   LO
   TS