General Information of the Compound
Compound ID
CP0400797
Compound Name
(4-cyclobutyl-1,4-diazepan-1-yl)(6-(3,4-dichlorophenoxy)pyridin-2-yl)methanone
    Show/Hide
Structure
Formula
C21H23Cl2N3O2
Molecular Weight
420.34
Canonical SMILES
Clc1ccc(Oc2cccc(n2)C(=O)N2CCCN(CC2)C2CCC2)cc1Cl
    Show/Hide
InChI
InChI=1S/C21H23Cl2N3O2/c22-17-9-8-16(14-18(17)23)28-20-7-2-6-19(24-20)21(27)26-11-3-10-25(12-13-26)15-4-1-5-15/h2,6-9,14-15H,1,3-5,10-13H2
    Show/Hide
InChIKey
BKTPKBQWTMYGGR-UHFFFAOYSA-N
Physicochemical Property
logP
4.8811
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
45.67
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 24771575
SID: 49693003
ChEMBL ID
CHEMBL1172644
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Ki = 160 nM
   TI
   LI
   LO
   TS