General Information of the Compound
Compound ID
CP0399189
Compound Name
2-[4-[2-[(2,4-dichlorophenyl)sulfonylamino]-4-(3-ethyl-1,2,4-oxadiazol-5-yl)phenoxy]-3-methoxyphenyl]acetic acid
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Structure
Formula
C25H21Cl2N3O7S
Molecular Weight
578.43
Canonical SMILES
CCc1noc(n1)-c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
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InChI
InChI=1S/C25H21Cl2N3O7S/c1-3-23-28-25(37-29-23)15-5-8-19(36-20-7-4-14(11-24(31)32)10-21(20)35-2)18(12-15)30-38(33,34)22-9-6-16(26)13-17(22)27/h4-10,12-13,30H,3,11H2,1-2H3,(H,31,32)
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InChIKey
SNDGAMZKEZTUNG-UHFFFAOYSA-N
Physicochemical Property
logP
5.8346
Rotatable Bonds
10
Heavy Atom Count
38
Polar Areas
140.85
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57392568
ChEMBL ID
CHEMBL1950876
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01054, Prostaglandin D2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 23 nM
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Protein ID: PT01171, Prostaglandin D2 receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 770 nM
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