General Information of the Compound
Compound ID
CP0398421
Compound Name
(4aR,10bR)-N-[(4-methoxyphenyl)methyl]-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazine-9-carboxamide
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Structure
Formula
C24H30N2O3
Molecular Weight
394.515
Canonical SMILES
CCCN1CCO[C@H]2[C@H]1CCc1ccc(cc21)C(=O)NCc1ccc(OC)cc1
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InChI
InChI=1S/C24H30N2O3/c1-3-12-26-13-14-29-23-21-15-19(7-6-18(21)8-11-22(23)26)24(27)25-16-17-4-9-20(28-2)10-5-17/h4-7,9-10,15,22-23H,3,8,11-14,16H2,1-2H3,(H,25,27)/t22-,23-/m1/s1
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InChIKey
NTVSBHFQAIUFRR-DHIUTWEWSA-N
Physicochemical Property
logP
3.7233
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
50.8
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 18397434
ChEMBL ID
CHEMBL485027
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3388.44 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS