General Information of the Compound
Compound ID
CP0398301
Compound Name
US9447038, 119
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Structure
Formula
C28H32ClN3O6
Molecular Weight
542.032
Canonical SMILES
COc1cc(CN(C(CC(O)=O)c2ccc(Cl)cc2)C2CCC2)ccc1OCCn1c(=O)ccn(C)c1=O
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InChI
InChI=1S/C28H32ClN3O6/c1-30-13-12-26(33)31(28(30)36)14-15-38-24-11-6-19(16-25(24)37-2)18-32(22-4-3-5-22)23(17-27(34)35)20-7-9-21(29)10-8-20/h6-13,16,22-23H,3-5,14-15,17-18H2,1-2H3,(H,34,35)
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InChIKey
SVEFRURJTNQNRL-UHFFFAOYSA-N
Physicochemical Property
logP
3.8585
Rotatable Bonds
12
Heavy Atom Count
38
Polar Areas
103
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90014377
ChEMBL ID
CHEMBL3938574
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03433, C-X-C chemokine receptor type 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000386 Flp-In-CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 152 nM
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