General Information of the Compound
Compound ID
CP0397228
Compound Name
(3-{(1R,2S,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(4-methoxy-phenyl)-but-1-enyl]-5-oxo-cyclopentylsulfanyl}-propylsulfanyl)-acetic acid
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Structure
Formula
C21H28O6S2
Molecular Weight
440.583
Canonical SMILES
COc1ccc(C[C@H](O)\C=C\[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(O)=O)cc1
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InChI
InChI=1S/C21H28O6S2/c1-27-16-6-3-14(4-7-16)11-15(22)5-8-17-18(23)12-19(24)21(17)29-10-2-9-28-13-20(25)26/h3-8,15,17-18,21-23H,2,9-13H2,1H3,(H,25,26)/b8-5+/t15-,17+,18-,21-/m1/s1
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InChIKey
AZYKMZOJGGSIIB-DXWQYRMGSA-N
Physicochemical Property
logP
2.4144
Rotatable Bonds
12
Heavy Atom Count
29
Polar Areas
104.06
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44304051
ChEMBL ID
CHEMBL305126
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02279, Prostacyclin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT02988, Prostaglandin E2 receptor EP1 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3100 nM
   TI
   LI
   LO
   TS
Protein ID: PT02989, Prostaglandin E2 receptor EP2 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1500 nM
   TI
   LI
   LO
   TS
Protein ID: PT02345, Prostaglandin E2 receptor EP3 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 220 nM
   TI
   LI
   LO
   TS
Protein ID: PT02346, Prostaglandin E2 receptor EP4 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 7.1 nM
   TI
   LI
   LO
   TS