General Information of the Compound
Compound ID
CP0392092
Compound Name
5-[4-(3,4-Dichloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentanenitrile
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Structure
Formula
C28H28Cl2N2O
Molecular Weight
479.451
Canonical SMILES
OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1
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InChI
InChI=1S/C28H28Cl2N2O/c29-25-13-12-24(20-26(25)30)28(33)15-18-32(19-16-28)17-7-14-27(21-31,22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-6,8-13,20,33H,7,14-19H2
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InChIKey
AEOKEWSIBHLUFL-UHFFFAOYSA-N
Physicochemical Property
logP
6.56688
Rotatable Bonds
7
Heavy Atom Count
33
Polar Areas
47.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11634351
SID: 16737512
ChEMBL ID
CHEMBL198313
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06171, G-protein coupled receptor homolog US28
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7 Chlorocebus aethiops (Green monkey)  1
1
IC50 = 38000 nM
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