General Information of the Compound
Compound ID
CP0391583
Compound Name
1-[4-[2-(7-methoxy-4,4-dimethylchromeno[4,3-c]pyrazol-2-yl)ethyl]piperazin-1-yl]-2,2-dimethylpropan-1-one
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Structure
Formula
C24H34N4O3
Molecular Weight
426.561
Canonical SMILES
COc1ccc2-c3nn(CCN4CCN(CC4)C(=O)C(C)(C)C)cc3C(C)(C)Oc2c1
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InChI
InChI=1S/C24H34N4O3/c1-23(2,3)22(29)27-12-9-26(10-13-27)11-14-28-16-19-21(25-28)18-8-7-17(30-6)15-20(18)31-24(19,4)5/h7-8,15-16H,9-14H2,1-6H3
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InChIKey
PUTMHKMKVABQQZ-UHFFFAOYSA-N
Physicochemical Property
logP
3.3765
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
59.83
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127029838
ChEMBL ID
CHEMBL3781521
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01298, Cannabinoid receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000065 HEK293-EBNA Homo sapiens (Human)  1
1
Ki > 40000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00834, Cannabinoid receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000065 HEK293-EBNA Homo sapiens (Human)  1
1
Ki = 6392 nM
   TI
   LI
   LO
   TS
Protein ID: PT05453, G-protein coupled receptor 55
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 0.69 nM
   TI
   LI
   LO
   TS
2
EC50 = 21.9 nM
   TI
   LI
   LO
   TS