General Information of the Compound
Compound ID
CP0389488
Compound Name
(4aR,11bR)-4-propyl-3,4a,5,6,8,11b-hexahydro-2H-[2]benzofuro[5,6-h][1,4]benzoxazin-10-one
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Structure
Formula
C17H21NO3
Molecular Weight
287.359
Canonical SMILES
CCCN1CCO[C@H]2[C@H]1CCc1cc3COC(=O)c3cc21
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InChI
InChI=1S/C17H21NO3/c1-2-5-18-6-7-20-16-13-9-14-12(10-21-17(14)19)8-11(13)3-4-15(16)18/h8-9,15-16H,2-7,10H2,1H3/t15-,16-/m1/s1
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InChIKey
PEJRVVYNELAPOR-HZPDHXFCSA-N
Physicochemical Property
logP
2.4551
Rotatable Bonds
2
Heavy Atom Count
21
Polar Areas
38.77
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
21

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24805287
SID: 49751491
ChEMBL ID
CHEMBL485128
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2041.74 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 2.291 nM
   TI
   LI
   LO
   TS
2
Ki = 7.586 nM
   TI
   LI
   LO
   TS