General Information of the Compound
Compound ID
CP0386080
Compound Name
2-[4-[4-[(dipropylamino)methyl]phenyl]phenyl]-1-piperidin-1-ylethanone
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Structure
Formula
C26H36N2O
Molecular Weight
392.587
Canonical SMILES
CCCN(CCC)Cc1ccc(cc1)-c1ccc(CC(=O)N2CCCCC2)cc1
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InChI
InChI=1S/C26H36N2O/c1-3-16-27(17-4-2)21-23-10-14-25(15-11-23)24-12-8-22(9-13-24)20-26(29)28-18-6-5-7-19-28/h8-15H,3-7,16-21H2,1-2H3
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InChIKey
NLDOPIPRAHLISM-UHFFFAOYSA-N
Physicochemical Property
logP
5.5306
Rotatable Bonds
9
Heavy Atom Count
29
Polar Areas
23.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44588348
ChEMBL ID
CHEMBL512197
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Ki = 251.19 nM
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