General Information of the Compound
Compound ID
CP0384686
Compound Name
((((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methylphosphonic acid
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Synonyms
MRS2782
Uridine-5'-alpha,beta-methylene-diphosphate triethylammonium salt
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Structure
Formula
C10H16N2O11P2
Molecular Weight
402.189
Canonical SMILES
O[C@@H]1[C@@H](COP(O)(=O)CP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
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InChI
InChI=1S/C10H16N2O11P2/c13-6-1-2-12(10(16)11-6)9-8(15)7(14)5(23-9)3-22-25(20,21)4-24(17,18)19/h1-2,5,7-9,14-15H,3-4H2,(H,20,21)(H,11,13,16)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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InChIKey
PDEGDTTUBZXACY-ZOQUXTDFSA-N
Physicochemical Property
logP
-2.507
Rotatable Bonds
6
Heavy Atom Count
25
Polar Areas
208.61
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
9
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44585949
ChEMBL ID
CHEMBL507060
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04712, 5'-nucleotidase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
Ki = 1830 nM
   TI
   LI
   LO
   TS
Protein ID: PT05434, P2Y purinoceptor 14
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
Protein ID: PT02796, P2Y purinoceptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1 Homo sapiens (Human)  3
1
EC50 = 339 nM
   TI
   LI
   LO
   TS
2
EC50 = 660 nM
   TI
   LI
   LO
   TS
3
EC50 = 700 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( MRS2782 )
Drug Name MRS2782
Target(s)
P2Y purinoceptor 6 (P2RY6)
Agonist