General Information of the Compound
Compound ID
CP0383997
Compound Name
(S)Ethyl 4-{4-Carboxy-2-[(2-phenylpyrimidine-4-carbonyl)amino]butyryl}piperazine-1-carboxylate
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Structure
Formula
C29H31N5O6
Molecular Weight
545.596
Canonical SMILES
CCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(nc(n1)-c1ccccc1)-c1ccccc1
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InChI
InChI=1S/C29H31N5O6/c1-2-40-29(39)34-17-15-33(16-18-34)28(38)22(13-14-25(35)36)32-27(37)24-19-23(20-9-5-3-6-10-20)30-26(31-24)21-11-7-4-8-12-21/h3-12,19,22H,2,13-18H2,1H3,(H,32,37)(H,35,36)/t22-/m0/s1
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InChIKey
QUXRBJHZZIKTTG-QFIPXVFZSA-N
Physicochemical Property
logP
3.0745
Rotatable Bonds
9
Heavy Atom Count
40
Polar Areas
142.03
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46233355
ChEMBL ID
CHEMBL598998
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 64 nM
   TI
   LI
   LO
   TS
2
Ki = 356 nM
   TI
   LI
   LO
   TS