General Information of the Compound
Compound ID
CP0380166
Compound Name
[2-[4-[[(E)-3-(4-acetylphenyl)prop-2-enoyl]amino]butyl]-3,4-dihydro-1H-isoquinolin-7-yl] trifluoromethanesulfonate
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Structure
Formula
C25H27F3N2O5S
Molecular Weight
524.561
Canonical SMILES
CC(=O)c1ccc(\C=C\C(=O)NCCCCN2CCc3ccc(OS(=O)(=O)C(F)(F)F)cc3C2)cc1
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InChI
InChI=1S/C25H27F3N2O5S/c1-18(31)20-7-4-19(5-8-20)6-11-24(32)29-13-2-3-14-30-15-12-21-9-10-23(16-22(21)17-30)35-36(33,34)25(26,27)28/h4-11,16H,2-3,12-15,17H2,1H3,(H,29,32)/b11-6+
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InChIKey
WRMSYILMRYXLAS-IZZDOVSWSA-N
Physicochemical Property
logP
4.0855
Rotatable Bonds
10
Heavy Atom Count
36
Polar Areas
92.78
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 17866220
ChEMBL ID
CHEMBL293347
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 251.19 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3.981 nM
   TI
   LI
   LO
   TS