General Information of the Compound
Compound ID
CP0379114
Compound Name
CHEMBL315209
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Formula
C28H32FN3O
Molecular Weight
445.582
Canonical SMILES
Fc1ccccc1\C=C\C(=O)N[C@H]1CC[C@H](CCN2CCc3ccc(cc3CC2)C#N)CC1
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InChI
InChI=1S/C28H32FN3O/c29-27-4-2-1-3-24(27)9-12-28(33)31-26-10-6-21(7-11-26)13-16-32-17-14-23-8-5-22(20-30)19-25(23)15-18-32/h1-5,8-9,12,19,21,26H,6-7,10-11,13-18H2,(H,31,33)/b12-9+/t21-,26-
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InChIKey
UICAAFBEFWZYOJ-WFCPMTAMSA-N
Physicochemical Property
logP
4.87648
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
56.13
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL315209
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 630.96 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 10 nM
   TI
   LI
   LO
   TS