General Information of the Compound
Compound ID
CP0378613
Compound Name
6-phenyl-9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline
    Show/Hide
Structure
Formula
C26H34N2O
Molecular Weight
390.571
Canonical SMILES
C(COc1ccc2C(CN3CCCC3c2c1)c1ccccc1)CN1CCCCC1
    Show/Hide
InChI
InChI=1S/C26H34N2O/c1-3-9-21(10-4-1)25-20-28-17-7-11-26(28)24-19-22(12-13-23(24)25)29-18-8-16-27-14-5-2-6-15-27/h1,3-4,9-10,12-13,19,25-26H,2,5-8,11,14-18,20H2
    Show/Hide
InChIKey
GLQKOPFSKTXMBM-UHFFFAOYSA-N
Physicochemical Property
logP
5.2238
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
15.71
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44438903
ChEMBL ID
CHEMBL240250
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  2
1
Ki = 0.9 nM
   TI
   LI
   LO
   TS
2
Ki = 4 nM
   TI
   LI
   LO
   TS