General Information of the Compound
Compound ID
CP0374972
Compound Name
2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide
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Structure
Formula
C32H32F6N2O2Si
Molecular Weight
618.694
Canonical SMILES
CC(C)(C)[Si](C)(C)OCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
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InChI
InChI=1S/C32H32F6N2O2Si/c1-30(2,3)43(4,5)42-19-26-28(27(21-11-7-6-8-12-21)24-13-9-10-14-25(24)40-26)29(41)39-18-20-15-22(31(33,34)35)17-23(16-20)32(36,37)38/h6-17H,18-19H2,1-5H3,(H,39,41)
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InChIKey
HXKCARPNNJLDND-UHFFFAOYSA-N
Physicochemical Property
logP
9.3912
Rotatable Bonds
7
Heavy Atom Count
43
Polar Areas
51.22
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11433531
SID: 16530917
ChEMBL ID
CHEMBL23982
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000441 UC-11MG Homo sapiens (Human)  1
1
IC50 = 17 nM
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