General Information of the Compound
Compound ID
CP0373993
Compound Name
1-ethyl-3-phenyl-N-[1-(4-pyrimidin-2-ylpiperazin-1-yl)propan-2-yl]thieno[2,3-c]pyrazole-5-carboxamide
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Structure
Formula
C25H29N7OS
Molecular Weight
475.622
Canonical SMILES
CCn1nc(-c2ccccc2)c2cc(sc12)C(=O)NC(C)CN1CCN(CC1)c1ncccn1
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InChI
InChI=1S/C25H29N7OS/c1-3-32-24-20(22(29-32)19-8-5-4-6-9-19)16-21(34-24)23(33)28-18(2)17-30-12-14-31(15-13-30)25-26-10-7-11-27-25/h4-11,16,18H,3,12-15,17H2,1-2H3,(H,28,33)
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InChIKey
QQNPMGDBNUSVCE-UHFFFAOYSA-N
Physicochemical Property
logP
3.5152
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
79.18
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46231856
ChEMBL ID
CHEMBL599348
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05900, P2X purinoceptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 501.19 nM
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