General Information of the Compound
Compound ID
CP0356698
Compound Name
N-[4-[4-[3-(methanesulfonamido)phenyl]piperazin-1-yl]butyl]naphthalene-2-carboxamide
    Show/Hide
Structure
Formula
C26H32N4O3S
Molecular Weight
480.634
Canonical SMILES
CS(=O)(=O)Nc1cccc(c1)N1CCN(CCCCNC(=O)c2ccc3ccccc3c2)CC1
    Show/Hide
InChI
InChI=1S/C26H32N4O3S/c1-34(32,33)28-24-9-6-10-25(20-24)30-17-15-29(16-18-30)14-5-4-13-27-26(31)23-12-11-21-7-2-3-8-22(21)19-23/h2-3,6-12,19-20,28H,4-5,13-18H2,1H3,(H,27,31)
    Show/Hide
InChIKey
PVEJYMIAJKGDRP-UHFFFAOYSA-N
Physicochemical Property
logP
3.5435
Rotatable Bonds
9
Heavy Atom Count
34
Polar Areas
81.75
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 127027384
ChEMBL ID
CHEMBL3758610
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 55 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1.6 nM
   TI
   LI
   LO
   TS