General Information of the Compound
Compound ID
CP0355177
Compound Name
N-[2-[3-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]ethyl]-3-(trifluoromethyl)benzamide
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Structure
Formula
C23H18F3N3O
Molecular Weight
409.411
Canonical SMILES
FC(F)(F)c1cccc(c1)C(=O)NCCc1cccc(c1)-c1cnc2[nH]ccc2c1
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InChI
InChI=1S/C23H18F3N3O/c24-23(25,26)20-6-2-5-18(13-20)22(30)28-9-7-15-3-1-4-16(11-15)19-12-17-8-10-27-21(17)29-14-19/h1-6,8,10-14H,7,9H2,(H,27,29)(H,28,30)
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InChIKey
DGMRBKNFUGWGID-UHFFFAOYSA-N
Physicochemical Property
logP
5.2212
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
57.78
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166062943
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01975, Cyclin-dependent kinase 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
IC50 = 6800 nM
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