General Information of the Compound
Compound ID
CP0354658
Compound Name
4-methyl-5-[4-methyl-5-[3-[1-[2-methyl-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole
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Structure
Formula
C23H26F3N5OS
Molecular Weight
477.556
Canonical SMILES
Cc1ncoc1-c1nnc(SCCCN2CC3CC3(C2)c2ccc(cc2C)C(F)(F)F)n1C
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InChI
InChI=1S/C23H26F3N5OS/c1-14-9-16(23(24,25)26)5-6-18(14)22-10-17(22)11-31(12-22)7-4-8-33-21-29-28-20(30(21)3)19-15(2)27-13-32-19/h5-6,9,13,17H,4,7-8,10-12H2,1-3H3
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InChIKey
KFCVKULFYARZLT-UHFFFAOYSA-N
Physicochemical Property
logP
4.86144
Rotatable Bonds
7
Heavy Atom Count
33
Polar Areas
59.98
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44627245
SID: 87554657
ChEMBL ID
CHEMBL1079814
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 100 nM
   TI
   LI
   LO
   TS