General Information of the Compound
Compound ID
CP0329089
Compound Name
(4-cyclobutylpiperazin-1-yl)(3-(piperidine-1-carbonyl)benzo[b]thiophen-5-yl)methanone
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Structure
Formula
C23H29N3O2S
Molecular Weight
411.571
Canonical SMILES
O=C(N1CCCCC1)c1csc2ccc(cc12)C(=O)N1CCN(CC1)C1CCC1
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InChI
InChI=1S/C23H29N3O2S/c27-22(26-13-11-24(12-14-26)18-5-4-6-18)17-7-8-21-19(15-17)20(16-29-21)23(28)25-9-2-1-3-10-25/h7-8,15-16,18H,1-6,9-14H2
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InChIKey
XRYJTISFHQDRSM-UHFFFAOYSA-N
Physicochemical Property
logP
3.8377
Rotatable Bonds
3
Heavy Atom Count
29
Polar Areas
43.86
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 52941001
ChEMBL ID
CHEMBL1270173
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Ki = 520 nM
   TI
   LI
   LO
   TS