General Information of the Compound
Compound ID
CP0329087
Compound Name
(3-((4-cyclobutylpiperazin-1-yl)methyl)-1H-indol-7-yl)(piperidin-1-yl)methanone
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Structure
Formula
C23H32N4O
Molecular Weight
380.536
Canonical SMILES
O=C(N1CCCCC1)c1cccc2c(CN3CCN(CC3)C3CCC3)c[nH]c12
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InChI
InChI=1S/C23H32N4O/c28-23(27-10-2-1-3-11-27)21-9-5-8-20-18(16-24-22(20)21)17-25-12-14-26(15-13-25)19-6-4-7-19/h5,8-9,16,19,24H,1-4,6-7,10-15,17H2
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InChIKey
UTTVMTPZXLDCKM-UHFFFAOYSA-N
Physicochemical Property
logP
3.4641
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
42.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25062740
SID: 56399683
ChEMBL ID
CHEMBL1269958
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Ki = 240 nM
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