General Information of the Compound
Compound ID
CP0313182
Compound Name
N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-naphthalen-2-ylpiperidine-1-carboxamide
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Structure
Formula
C37H46N6O2
Molecular Weight
606.815
Canonical SMILES
Cc1cc(C[C@@H](NC(=O)N2CCC(CC2)c2ccc3ccccc3c2)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12
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InChI
InChI=1S/C37H46N6O2/c1-26-21-27(22-32-25-38-40-35(26)32)23-34(36(44)42-19-13-33(14-20-42)41-15-5-2-6-16-41)39-37(45)43-17-11-29(12-18-43)31-10-9-28-7-3-4-8-30(28)24-31/h3-4,7-10,21-22,24-25,29,33-34H,2,5-6,11-20,23H2,1H3,(H,38,40)(H,39,45)/t34-/m1/s1
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InChIKey
PGUPJMQJNPDQPV-UUWRZZSWSA-N
Physicochemical Property
logP
6.00172
Rotatable Bonds
6
Heavy Atom Count
45
Polar Areas
84.57
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127028128
ChEMBL ID
CHEMBL3770364
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04285, Calcitonin gene-related peptide 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
IC50 = 14 nM
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