General Information of the Compound
Compound ID
CP0311748
Compound Name
2-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindole
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Structure
Formula
C26H34N2O3
Molecular Weight
422.569
Canonical SMILES
COc1cc2CCN(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)Cc2cc1OC
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InChI
InChI=1S/C26H34N2O3/c1-29-24-6-4-5-21-22(24)8-7-19-15-28(17-23(19)21)12-11-27-10-9-18-13-25(30-2)26(31-3)14-20(18)16-27/h4-6,13-14,19,23H,7-12,15-17H2,1-3H3/t19-,23+/m0/s1
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InChIKey
WKPITOGUWYLINO-WMZHIEFXSA-N
Physicochemical Property
logP
3.7323
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
34.17
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10622156
SID: 15652617
ChEMBL ID
CHEMBL59575
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02075, Alpha-1D adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000041 LTK- Mus musculus (Mouse)  1
1
Ki = 83.4 nM
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   LI
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