General Information of the Compound
Compound ID
CP0308489
Compound Name
4-methyl-5-[4-methyl-5-[3-[1-[2-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole
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Structure
Formula
C22H24F3N5OS
Molecular Weight
463.529
Canonical SMILES
Cc1ncoc1-c1nnc(SCCCN2CC3CC3(C2)c2ccccc2C(F)(F)F)n1C
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InChI
InChI=1S/C22H24F3N5OS/c1-14-18(31-13-26-14)19-27-28-20(29(19)2)32-9-5-8-30-11-15-10-21(15,12-30)16-6-3-4-7-17(16)22(23,24)25/h3-4,6-7,13,15H,5,8-12H2,1-2H3
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InChIKey
KYPWROFHQUYOCS-UHFFFAOYSA-N
Physicochemical Property
logP
4.55302
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
59.98
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44627238
SID: 87554545
ChEMBL ID
CHEMBL1080189
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 794.33 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 31.62 nM
   TI
   LI
   LO
   TS