General Information of the Compound
Compound ID
CP0297532
Compound Name
4-methyl-5-[4-methyl-5-[3-[1-[4-(trifluoromethyl)phenyl]-4-azabicyclo[5.1.0]octan-4-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole
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Structure
Formula
C24H28F3N5OS
Molecular Weight
491.583
Canonical SMILES
Cc1ncoc1-c1nnc(SCCCN2CCC3CC3(CC2)c2ccc(cc2)C(F)(F)F)n1C
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InChI
InChI=1S/C24H28F3N5OS/c1-16-20(33-15-28-16)21-29-30-22(31(21)2)34-13-3-10-32-11-8-19-14-23(19,9-12-32)17-4-6-18(7-5-17)24(25,26)27/h4-7,15,19H,3,8-14H2,1-2H3
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InChIKey
FOUYNUWEFKTMDR-UHFFFAOYSA-N
Physicochemical Property
logP
5.33322
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
59.98
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 52947694
ChEMBL ID
CHEMBL1257809
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3.981 nM
   TI
   LI
   LO
   TS