General Information of the Compound
Compound ID
CP0297520
Compound Name
5-phenyl-N-(4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)butyl)pyridin-2-amine
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Structure
Formula
C26H29F3N4
Molecular Weight
454.54
Canonical SMILES
FC(F)(F)c1cccc(c1)N1CCN(CCCCNc2ccc(cn2)-c2ccccc2)CC1
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InChI
InChI=1S/C26H29F3N4/c27-26(28,29)23-9-6-10-24(19-23)33-17-15-32(16-18-33)14-5-4-13-30-25-12-11-22(20-31-25)21-7-2-1-3-8-21/h1-3,6-12,19-20H,4-5,13-18H2,(H,30,31)
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InChIKey
UDUOGLZZYDDSKR-UHFFFAOYSA-N
Physicochemical Property
logP
5.7817
Rotatable Bonds
8
Heavy Atom Count
33
Polar Areas
31.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11655403
SID: 16758922
ChEMBL ID
CHEMBL1223801
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 1.1 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 143 nM
   TI
   LI
   LO
   TS