General Information of the Compound
Compound ID
CP0294507
Compound Name
(3-(morpholinomethyl)-1H-indol-7-yl)(piperazin-1-yl)methanone
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Structure
Formula
C18H24N4O2
Molecular Weight
328.416
Canonical SMILES
O=C(N1CCNCC1)c1cccc2c(CN3CCOCC3)c[nH]c12
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InChI
InChI=1S/C18H24N4O2/c23-18(22-6-4-19-5-7-22)16-3-1-2-15-14(12-20-17(15)16)13-21-8-10-24-11-9-21/h1-3,12,19-20H,4-11,13H2
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InChIKey
IMPCUXGHYKTKKV-UHFFFAOYSA-N
Physicochemical Property
logP
1.0455
Rotatable Bonds
3
Heavy Atom Count
24
Polar Areas
60.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 52943401
ChEMBL ID
CHEMBL1269957
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Ki = 2130 nM
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