General Information of the Compound
Compound ID
CP0289973
Compound Name
5-(benzenesulfonyl)-N-[1-[(2S)-1-(pyridine-4-carbonyl)pyrrolidine-2-carbonyl]piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
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Structure
Formula
C29H29F3N4O6S2
Molecular Weight
650.701
Canonical SMILES
FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)c1ccncc1)S(=O)(=O)c1ccccc1
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InChI
InChI=1S/C29H29F3N4O6S2/c30-29(31,32)24-9-8-23(43(39,40)22-5-2-1-3-6-22)19-26(24)44(41,42)34-21-12-17-35(18-13-21)28(38)25-7-4-16-36(25)27(37)20-10-14-33-15-11-20/h1-3,5-6,8-11,14-15,19,21,25,34H,4,7,12-13,16-18H2/t25-/m0/s1
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InChIKey
WAWYMBXODUTKBX-VWLOTQADSA-N
Physicochemical Property
logP
3.5073
Rotatable Bonds
7
Heavy Atom Count
44
Polar Areas
133.82
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
44

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25187401
SID: 57295145
ChEMBL ID
CHEMBL454478
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04857, Proto-oncogene Wnt-3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000043 U2OS Homo sapiens (Human)  1
1
EC50 = 350 nM
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