General Information of the Compound
Compound ID
CP0266797
Compound Name
5-[3-[2-(1,3-dihydroisoindol-2-yl)ethyl]-2-oxoimidazolidin-1-yl]-2-fluorobenzonitrile
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Structure
Formula
C20H19FN4O
Molecular Weight
350.397
Canonical SMILES
Fc1ccc(cc1C#N)N1CCN(CCN2Cc3ccccc3C2)C1=O
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InChI
InChI=1S/C20H19FN4O/c21-19-6-5-18(11-17(19)12-22)25-10-9-24(20(25)26)8-7-23-13-15-3-1-2-4-16(15)14-23/h1-6,11H,7-10,13-14H2
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InChIKey
DGTBKKBZRIVWMP-UHFFFAOYSA-N
Physicochemical Property
logP
2.95518
Rotatable Bonds
4
Heavy Atom Count
26
Polar Areas
50.58
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45268987
ChEMBL ID
CHEMBL562176
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 794.33 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 15.85 nM
   TI
   LI
   LO
   TS