General Information of the Compound
Compound ID
CP0261352
Compound Name
(4S)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid
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Synonyms
BX 667
BX-667
BX667
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Structure
Formula
C29H38N4O9
Molecular Weight
586.642
Canonical SMILES
CCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(O)=O)NC(=O)c1cc(OC(C)(C)C(=O)OCC)c2ccc(C)cc2n1
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InChI
InChI=1S/C29H38N4O9/c1-6-40-27(38)29(4,5)42-23-17-22(30-21-16-18(3)8-9-19(21)23)25(36)31-20(10-11-24(34)35)26(37)32-12-14-33(15-13-32)28(39)41-7-2/h8-9,16-17,20H,6-7,10-15H2,1-5H3,(H,31,36)(H,34,35)/t20-/m0/s1
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InChIKey
PHDMSNZRDFPYNQ-FQEVSTJZSA-N
Physicochemical Property
logP
2.52762
Rotatable Bonds
11
Heavy Atom Count
42
Polar Areas
164.67
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16681707
SID: 26657363
ChEMBL ID
CHEMBL2172275
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02449, P2Y purinoceptor 12
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 86 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 29 nM
Clinical Information about the Compound
Drug 1 ( BX 667 )
Drug Name BX 667
Target(s)
P2Y purinoceptor 12 (P2RY12)
Antagonist